Prostate Cancer Awareness Month

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Add your voice to the chorus of change in the fight against prostate cancer. Join our patient community this November and contribute to the cause.

The Significance of Prostate Cancer Awareness Month

_Prostate Cancer Awareness Month serves as a platform to educate and inform individuals about prostate cancer, its risk factors, symptoms, and the significance of early detection. This a time dedicated to raising awareness about this prevalent and often silent disease that affects millions of men worldwide. While prostate cancer is the second most common cancer among men, it is also one of the most treatable if detected early. This month, we aim to shed light on the importance of early detection, amplify the voices of prostate cancer patients, and explore the crucial role of patient participation in research.

Understanding Prostate Cancer

_The prostate is a walnut-sized gland located in the male reproductive system. It is vital in producing seminal fluid and supporting healthy urine flow. Prostate cancer develops when cells in the prostate gland grow abnormally, forming a tumor. These abnormal cells can invade surrounding tissues and spread to other body parts, making early detection and treatment essential.

Types of Prostate Cancer

_Prostate cancer can manifest in various ways, and its behavior can differ from person to person. Generally, prostate cancer is categorized into different types based on how the cancer cells appear under a microscope and how they behave. The primary types of prostate cancer include:

0 Acinar Adenocarcinoma

This is the most common type of prostate cancer, accounting for around 90% or more of diagnosed cases. It originates in the gland cells (adenocarcinoma) of the prostate and usually grows slowly. Acinar adenocarcinoma may still spread beyond the prostate gland if left untreated.

0 Transitional Cell (Urothelial) Cancer

This type of cancer originates in the cells lining the urethra. It is less common than adenocarcinoma and may behave differently in terms of growth and spread.

0 Ductal Adenocarcinoma

A less common form, ductal adenocarcinoma begins in the cells lining the ducts of the prostate gland. It can be more aggressive than acinar adenocarcinoma and may have a tendency to grow and spread more rapidly.

0 Small Cell Carcinoma

Small cell carcinoma of the prostate is rare and tends to grow and spread quickly. It may require different treatment approaches compared to adenocarcinoma.

.. These classifications help oncologists understand the behaviour of the cancer and determine the most suitable treatment options. Additionally, prostate cancers can also be categorized based on their aggressiveness using grading systems such as the Gleason score, which assesses the cancer cells' appearance under a microscope.

Symptoms:

. Prostate cancer symptoms may not always be evident in the early stages of the disease. However, as the cancer progresses, some individuals may experience symptoms related to the prostate or urinary system:

_ Urinary Changes - Changes in urinary habits might include increased frequency of urination, especially at night (nocturia), difficulty starting or stopping urine flow, weak urine stream, inability to empty the bladder completely, or experiencing a sudden urge to urinate.

_Blood in Urine or Semen - Hematuria (blood in the urine) or blood in semen can sometimes be a symptom of prostate cancer. However, these symptoms can also be caused by other conditions such as infections or non-cancerous prostate enlargement.

_Erectile Dysfunction - Difficulty in achieving or maintaining an erection might occur in some cases, but this can also be due to various other health factors besides prostate cancer.

_Pain and Discomfort - Some individuals may experience discomfort or pain in the pelvic area, lower back, hips, or upper thighs. This discomfort might arise from cancer spreading to nearby areas or due to cancer pressing on nerves or other tissues.

_Bone Pain - Advanced prostate cancer might spread (metastasize) to the bones, leading to bone pain, especially in the spine, hips, or ribs. This pain might be constant or worsen at night.

Risk factors:

. Several factors can contribute to an individual's risk of developing prostate cancer.

_ Age - Age is a significant risk factor for prostate cancer. The likelihood of developing prostate cancer increases with age, particularly in men over 50. The majority of prostate cancer cases occur in men over the age of 65.

_ Family History and Genetics - Having a family history of prostate cancer increases the risk. If a close male relative, such as a father or brother, has had prostate cancer, the risk is higher. Certain inherited gene mutations, such as BRCA1 and BRCA2, may also elevate the risk of prostate cancer.

_Ethnicity - Prostate cancer occurs more frequently in certain ethnic groups. African American men have a higher risk of developing prostate cancer compared to men of other ethnicities. They are also more likely to be diagnosed at an advanced stage and have a more aggressive form.

_Diet and Lifestyle - While the evidence isn't conclusive, dietary factors and lifestyle choices may impact prostate cancer risk. A diet high in red and processed meats, high-fat dairy products, and a low intake of fruits and vegetables may slightly increase the risk.

_Obesity - Some studies suggest that obesity might be associated with an increased risk of developing more aggressive forms of prostate cancer. However, more research is needed to fully understand this relationship.

_Exposure to Certain Chemicals - Exposure to certain environmental factors or occupational hazards, such as exposure to Agent Orange or certain chemicals used in manufacturing, might also contribute to an increased risk of prostate cancer.

Treatment Options!

. The treatment options for prostate cancer depend on various factors including the stage of cancer, the aggressiveness of the cancer cells, the individual's overall health, and personal preferences:

_Active Surveillance or Watchful Waiting: For low-risk prostate cancer or in cases where the cancer is slow-growing and not causing symptoms, the healthcare provider might recommend active surveillance. This involves regular monitoring through PSA tests, digital rectal exams, and possibly biopsies to track any changes in the cancer. Treatment may be deferred unless the cancer shows signs of progression.

_ Surgery: Radical prostatectomy involves surgical removal of the entire prostate gland and, in some cases, nearby tissues. This procedure might be recommended for cancer that is confined to the prostate gland and has not spread beyond it.

_ Radiation Therapy: Radiation therapy uses high-energy beams to kill cancer cells. It can be delivered externally through a machine (external beam radiation therapy) or internally by placing radioactive seeds into the prostate (brachytherapy). Radiation therapy might be used as the primary treatment or combined with other treatments.

_ Hormone Therapy: Prostate cancer cells often rely on male hormones, particularly testosterone, to grow. Hormone therapy aims to reduce the levels of male hormones in the body or block their effects on cancer cells. This can be done through medications or surgical removal of the testicles (orchiectomy).

_ Chemotherapy: In cases where prostate cancer has spread beyond the prostate and hormone therapy is no longer effective, chemotherapy drugs may be used to kill cancer cells or slow their growth. Chemotherapy is typically used in more advanced stages of prostate cancer.

_ Immunotherapy: Some newer treatments involve using drugs that help the immune system recognize and attack cancer cells. Immunotherapy might be recommended for certain types of advanced prostate cancer.

_ Targeted Therapy: Targeted drugs are designed to specifically target certain abnormalities or proteins in cancer cells. These drugs may be used in conjunction with other treatments for advanced prostate cancer.

Early Detection: The Best Remedy

_ Early detection of prostate cancer offers the best chance for successful treatment and survival. When detected early, prostate cancer is often highly treatable, with a five-year survival rate of nearly 100%. Regular screenings, such as a prostate-specific antigen (PSA) test and a digital rectal exam, can help identify prostate cancer early, even before symptoms appear.

How to get early detection?

. Early detection of prostate cancer is crucial for better treatment outcomes. Here are several steps and methods for early detection:

0 PSA (Prostate-Specific Antigen) Test:

The PSA blood test measures the levels of a protein produced by the prostate gland. Elevated PSA levels can indicate various prostate issues, including cancer. However, PSA levels can also be elevated due to non-cancerous conditions. Discuss with your doctor whether a PSA test is appropriate for you based on your age, risk factors, and overall health.

0 Digital Rectal Examination (DRE):

During a DRE, a healthcare provider inserts a gloved, lubricated finger into the rectum to feel the prostate gland for abnormalities in size, texture, or shape. Although it's less sensitive than the PSA test, it can help detect abnormalities in the prostate.

Insights from Senior Prostate Cancer Doctors

In March 2021, Mike sought a PSA test despite lacking symptoms. After a referral from his GP, a specialist found a concerning node. Further tests revealed aggressive cancer. Following a prostatectomy, ongoing treatments manage rising PSA levels. Mike advocates for support, positivity, and intention in facing prostate cancer, embracing the term "cancer warrior," not just surviving but thriving, promoting awareness and strength in unity.

Mike Prostate Cancer Warrior

Insights from Senior Prostate Cancer Doctors

. We spoke to senior cancer doctors who have extensive experience in treating prostate cancer. They shared their insights into the disease, emphasizing the importance of early detection and the advancements in treatment options. Their knowledge can provide valuable guidance for both patients and their families.

0 Patrick C. Walsh - Urologist

“The clearest short-term yardstick may be the PSA nadir (discussed above). One study of 743 patients at Memorial Sloan-Kettering Cancer Center in New York confirmed that higher-intensity radiation does a better job of achieving a rock- bottom PSA level. Of the men who received higher doses—76 to 81 Gy—90 percent achieved a PSA nadir of 1.0 ng/ml or less; 76 percent of men who received 70 Gy and 56 percent of men who received 64.8 Gy achieved those low PSA levels. But there was a trade-off—the men who received higher doses of radiation also had a significantly higher rate of gastrointestinal side effects, urinary tract complications, and impotence. To overcome these side effects at high doses, intensity-modulated radiation therapy”

0 David - Oncologist

Early detection significantly improves the prognosis for prostate cancer. Regular screenings, including PSA tests and digital rectal exams, are crucial, especially for individuals at higher risk due to age or family history.

The Role of Research

_Prostate cancer survivorship encompasses the period after successful treatment, focusing on managing long-term effects, maintaining overall health, and embracing a fulfilling life. Patient participation in research is crucial for advancing the understanding of prostate cancer and developing more effective treatments and supportive care strategies. Here are several ways you can actively participate in cancer research initiatives:

0 Clinical Trials:

Many research studies and clinical trials are ongoing to test new treatments and early detection methods. If you or a loved one is diagnosed with cancer, consider enrolling in a clinical trial to contribute to medical advancements.

0 Donations:

Support organizations and institutions conducting cancer research by making donations. Even a small contribution can go a long way in funding critical research efforts.

0 Advocacy:

Get involved in advocacy groups dedicated to cancer. These groups work to raise awareness, influence policies, and promote research funding.

0 Volunteer:

Many organizations and research institutions welcome volunteers who can assist with various tasks, from fundraising to patient support.

0 Participate in Surveys and Studies:

Keep an eye out for opportunities to participate in surveys or studies related to cancer.

Survience: A Beacon of Hope

. Survience is a Market Research and Consulting firm dedicated to bringing out the true voices of patients affected with various life-threatening diseases. We enable a bridge between patients and researchers, capturing opinions and experiences through different methodologies of research data collection. By participating with Survience, in our survey initiatives, patients and caregivers have the opportunity to share their experiences, concerns, and ideas directly with researchers and companies. Your participation can make a significant impact by ensuring that the voices of patients reach the right researchers, leading to advancements in diagnosis, treatment, and support. Prostate Cancer Awareness Month serves as a reminder of the importance of early detection, the resilience of prostate cancer patients, and the transformative power of patient participation in research. By combining early detection strategies, expert medical guidance, patient engagement, and ongoing research, we can work towards a future where prostate cancer is no longer a life-threatening disease but a manageable condition. The voices of prostate cancer patients are essential in shaping research priorities and ensuring that treatment options align with the needs and concerns of patients. By sharing their experiences and perspectives, patients can help researchers develop more patient-centered approaches to prostate cancer care.